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These sex-determining mechanisms cause the two sexes to differ in their dose of X chromosomes, yet both sexes require equivalent levels of X-chromosome gene products.

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In mammals, flies, and worms, sex is determined by distinctive regulatory mechanisms that cause males (XO or XY) and females (XX) to differ in their dose of X chromosomes.

In each species, an essential X chromosome-wide process called dosage compensation ensures that somatic cells of either sex express equal levels of X-linked gene products.

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