Start Xexx boren

Xexx boren

Click on the mutations for more specific information.), respectively] signaling pathways.

A subset of TNFRs such as the lymphotoxin-β receptor (LT-βR), CD40, B-cell-activating factor receptor (BAFFR) and receptor activator of Nf-κB (RANK) can activate the canonical or non-canonical NF-κB signaling pathways. (1994) The Immune Responses in CD40-Deficient Mice: Impaired Immunoglobulin Class Switching and Germinal Center Formation.

In the non-canonical pathway, the receptors bind to TRAFs to regulate NIK activity.

The IKK complex phosphorylates both IκB, p105 and TPL2 (or MAP3K8), resulting in IκB and p105 ubiquitination and degradation (small pink circles) by 26S proteasome.

Degradation of IκB releases activated NF-κB dimers for translocation to the nucleus. (1996) Expansion Or Elimination of B Cells in Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., and Kikutani, H.

Jak3 activation results in STAT3 phosphorylation, activation, and translocation to the nucleus.

Jak3 is not required for CD40-mediated B cell proliferation, isotype switching, or upregulation of ICAM-1 or CD80 . M., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z.

), wherein 2 variant homozygotes departed phenotypically from 8 homozygous reference mice and 6 heterozygous mice (Figure 2). The mutation results in an cysteine (C) to arginine (R) substitution at position 23 (C23R) in all of the isoforms of the CD40 protein, and is strongly predicted by Poly Phen-2 to be benign (score = 0.013) ).